RNA Details
Disease Name
scleroderma systemic
Tissue
skin
RNA Symbol
CCR7
RNA ID
RNA Type
mRNA
Alteration Pattern
dysregulation
Species
homo sapiens
Detection Methods
RT-PCR
Target
NA
Pathway
NA
PubMed ID
Title
Significantly increased CCL5/RANTES and CCR7 mRNA levels in localized scleroderma
Year
2011
Function
"We could confirm data of previous studies indicating that gene expression of il-6 is up-regulated in ls lesions as compared to healthy skin. Moreover, we have shown for the first time a significant increase of mrna levels of ccr7 and ccl5;Rantes in ls lesions indicating an important pathogenetic role of chemokines in ls."